Journal of Liver Cancer

Myoung Soo Kim

2 Articles

Curative liver transplantation after lung resection for advanced hepatocellular carcinoma with lung metastasis and inferior vena cava tumor thrombosis: a case report: Dong Jin Joo, Do Young Kim, Jinsil Seong, Hyun Jeong Kim, Jae Geun Lee, Dai Hoon Han, Gi Hong Choi, Myoung Soo Kim, Jin Sub Choi, Soon Il Kim; J Liver Cancer. 2021;21(2):181-186. Published online September 30, 2021; DOI: https://doi.org/10.17998/jlc.2021.09.08

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Hepatocellular carcinoma (HCC) with distant metastasis is an absolute contraindication for liver transplantation (LT). However, it is still unclear whether LT is feasible or acceptable in such patients, albeit after being treated with a multidisciplinary approach and after any metastatic lesion is ruled out. We report one such successful treatment with living donor LT (LDLT) after completely controlling far-advanced HCC with inferior vena cava tumor thrombosis and multiple lung metastases. The patient has been doing well without HCC recurrence for eight years since LDLT. The current patient could be an anecdotal case, but provides a case for expanding LDLT indications in the context of advanced HCC and suchlike.

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Inferior Vena Cava Thrombectomy and Stenting as Bridge to Liver Transplantation After Radiotherapy-Induced Thrombosis
Raphael PH Meier, Shani Kamberi, Josue Alvarez-Casas, Barton F. Lane, Chandra S. Bhati, Saad Malik, William Twaddell, Kirti Shetty, Adam Fang, Hyun S. Kim, Daniel G. Maluf
Progress in Transplantation.2023;[Epub] CrossRef

Hepatocellular carcinoma and Liver transplantation: Myoung Soo Kim; Journal of the Korean Liver Cancer Study Group. 2007;7(1):35-40. Published online June 30, 2007

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Abstract PDF: Liver transplantation is the prime management for early hepatocellular carcinoma with liver cirrhosis that is not candidate for surgical resection. Milan criteria, single tumor less than 5 cm or less than three tumors with less than 3 cm, is accepted as an indication for liver transplantation. The extended criteria do not show reliable result in long-term recurrent-free survival rate. Shortage of donor and following high drop-out rate during waiting time are main obstacle to liver transplantation, which can be alleviated by the living donor liver transplantation and priority policies in deceased donor liver allocation. The pre-operative loco-regional therapy, such as transarterial chemoembolization (TACE), radiofrequency ablation (RFA) and regional surgical resection, decreases the drop-out rate for waiting time and supplies time for preparing the liver transplantation. Generally acceptable recurrence rate after liver transplantation is less than 15%. The size of mass, vascular or lymphatic-invasion, low grade tumor and high pre-operative level of alpha-Fetoprotein (AFP) are risk factors for recurrence. The prognosis of recurred hepatocellular carcinoma is fatal. Neoadjuvant chemotherapy after liver transplantation cannot prolong the patient survival rate and decrease the recurrence rate. Above 50% of recurrence-free patient survival rate at post-transplant 5 years is reliable result after liver transplantation in hepatocellular carcinoma. The survival rate is improved after mid-1990, and is reported as 60-70% at post-transplant 5 years. The living donor liver transplantation shows more superior survival rate than deceased donor liver transplantation.